Preliminary Program

All ASMS program activities are being held in The Pavilion, see Island Grand map.

Detailed Final Program with Posters

Thursday, January 19, 2023

6:00 - 7:00 pm, Registration

7:00 - 7:10 pm, Opening Remarks, Michael T. Marty, Wendy Sandoval and Julian Whitelegge

7:10 - 8:10 pm, Keynote Lecture: Mass Spectrometry of Membrane Proteins in Complex with Lipids, Art Laganowsky (Texas A&M University)

8:10 - 10:00 pm, Reception

Friday, January 20, 2023

7:30- 8:30 am, Continental Breakfast

8:30 - 9:30 am, Membrane Protein Sample Preparation
  • Native Top-Down Mass Spectrometry with Electrons and Collisions of Membrane Protein Complexes, Joseph Loo (UCLA)
  • Surface Induced Dissociation of Membrane Peptides and Proteins from Nanodiscs and Micelles, Vicki Wysocki (Ohio State University)

9:30 - 10:00 am, Coffee Break

10:00 - 12:00 pm, Instrumentation

  • Deorphanizing Tough Membrane Targets Using Recombinant Extracellular Vesicles, Shengya  Cao (Genentech)
  • Hydrophobic Protein Analysis in Industry: From Native-MS to High Throughput-MS Therapeutic Project Support, Iain Campuzano (Amgen)
  • Membrane Protein Complexes and their Environments, Nina Morgner (Goethe University Frankfurt)
  • Developments in the Analysis of Membrane Proteins on Orbitrap Platforms, Rosa Viner (Thermo Fisher Scientific)

12:00 - 12:15 pm, Group Photo

12:15 - 1:15 pm, Group Lunch, provided by ASMS

1:15 - 2:15 pm  Ion Mobility

  • Collision Induced Unfolding of Membrane Proteins and their Complexes, Brandon Ruotolo (University of Michigan)
  • Probing Gibbs Energy Landscape of Proteins: Variable Temperature-ESI and Ion Mobility-High Resolution Mass Spectrometry, David Russell (Texas A&M University)

2:15 - 2:55 pm, Talks promoted from abstracts

  • Single Cardiomyocytes Membrane Protein Content, Jenny Van Eyk, Cedar Sinai Medicial Center
  • Imaging Mass Spectrometry of Integral Membrane Proteins, Kevin Schey, Vanderbilt University

2:55 - 7:00 pm, Free Time

7:00 - 8:20 pm, Submitted Talks I

  • Exploring the pharmacology of GPCRs by native MS results in identification of endogenous ions that serve as positive allosteric modulators, Idlir Liko (OMass Therapeutics)
  • High-level daptomycin resistance is supported by increased membrane fluidity in Staphylococcus aureus with defective phosphatidylglycerol synthesis, Kelly Hines (University of Georgia)
  • 2-minute Flash Talks for Poster Presentations

8:20 - 10:00 pm, Poster Session I

Saturday, January 21, 2023

7:00 - 8:30 am, Continental Breakfast

7:30 - 8:30 am, Fully Integrated Native MS Workflow Discussion Panel, Vicki Wysocki (Ohio State University), Optional

8:30 - 10:00 am, Membrane Mimetics

  • Native MS and Lipidomics for Measuring Membrane Protein-Lipid Interactions in Heterogeneous Nanodiscs, Michael T. Marty (University of Arizona)
  • Gabor Transform Tools for Mass Spectrometry Characterization of Nanodiscs and Membrane Proteins, James Prell (University of Oregon)
  • Integrative Structural Mass Spectrometry to Interrogate Amphipol-Protein Assemblies and Inform on the Molecular Mechanism of Outer Membrane Protein Biogenesis, Antonio Calabrese (University of Leeds)

10:00 - 10:30 am, Coffee Break

10:30 - 12:00 pm, Biophysical Characterization

  • MS and EM - A Marriage Made in the Membrane? Frank Sobott (University of Leeds)
  • Unlocking the Functional Dynamics of Membrane Transporters by HDX-MS, Argyris Politis (University of Manchester)
  • Protein Interactions in Synaptic Vesicles and in the Neuronal Synapse Studied by Structural Mass Spectrometry, Carla Schmidt (HALOmem, Martin Luther University Halle-Wittenberg)

12:00 - 1:30 pm, Lunch on your own

1:30 - 3:00 pm, Proteomics

  • How Does a Single Mutation in the Membrane Protein CFTR Cause the Disease Cystic Fibrosis, John Yates (Scripps Research Institute)
  • Maintaining Higher-Order Structure while Removing Non-Covalent Associations for Effective Electrospray Ionization of Integral Membrane Proteins, Julian Whitelegge (UCLA)
  • Ultraviolet Photodissociation for Analysis of Membrane Protein Complexes, Jennifer Brodbelt (University of Texas)

3:00 - 3:30 pm, Coffee Break

3:30 - 5:00 pm, Membrane Protein Structural Biology and Biophysics

  • 3D Structure Determination of Protein Complexes Using Matrix-Landing Mass Spectrometry, Josh Coon (University of Wisconsin)
  • Transmembrane Helices Mediate the Formation of a Stable Ternary Complex Composed of Cytochrome b5, Cytochrome B5 Reductase and Stearoyl-Coa Desaturase-1, Ming Zhou (Baylor College of Medicine)
  • Direct determination of organization of membrane protein and lipids from intact customizable lipid bilayers, Kallol Gupta (Yale University)

7:00 - 8:20 pm, Submitted Talks II

  • Deciphering the allosteric regulation of the NBD1 domain of CFTR channel by HDX-MS and single-molecule FRET, Chloe Martens (Université Libre de Bruxelles)
  • A Tailored Approach for the Analysis of Membrane Proteins from Tissue using Native Nano-DESI Mass Spectrometry, Emma Sisley (University of Birmingham)
  • 2-minute Flash Talks for Poster Presentations

8:20 - 10:00 pm, Poster Session II

Sunday, January 22, 2023

7:00 - 8:30 am, Continental Breakfast

8:30 - 10:00 am, Glycosylation and Lipids

  • MS support for Membrane Protein efforts in Structural Biology, Wendy Sandoval (Genentech)
  • MS-Based Investigations of Social and Anti-Social Distancing at the Cell Surface, Cathy Costello (Boston University School of Medicine)
  • Fingerprinting the Unique Lipidome of Membrane Proteins, Erin Baker (University of North Carolina at Chapel Hill)

10:00 - 10:15 am, Coffee Break

10:15 - 11:15 am, Keynote Lecture: Membrane Proteins in Context, Carol Robinson (University of Oxford)

11:15 - 11:30 am, Closing Remarks, Michael T. Marty, Wendy Sandoval and Julian Whitelegge