Conferences

Preliminary Program

Opening Lecture

  • Patrick Limbach (Labyrinth Partners Consulting), Decoding the Chemical Language of RNA by Mass Spectrometry

Sample Preparation for Nucleic Acid Assays by LC-MS

  • Eric Wolf (NEB), Sequence-Specific RNases for Bottom-Up RNA LC-MS/MS: New Tools and Workflows
  • Balu Addepalli (Waters), RNase MC1 and Cusativin: pH-Modulated Cleavages for end-to-end analysis of RNA Therapeutics
  • Afrand Kamali (Novo Nordisk), Current and Emerging Extraction Methods for LC-MS Bioanalysis of Oligonucleotide Therapeutics

Strategies for the Optimization of the Chromatographic Separation of Nucleic Acids

  • Michael Bartlett (University of Georgia), Fundamentals of Ion-Pair Reversed Phase Liquid Chromatography Mass Spectrometry
  • Todd Maloney (Eli Lilly)
  • Martin Gilar (Waters)

Data Processing and Interpretation for LC-MS Data

  • Sam Wein (University of Tuebingen), Scaling RNA Mass Spectrometry: Robust Identification and Label-Free Quantification with NucleicAcidSearchEngine
  • James Williamson (Scripps), Pytheus
  • Daniele Fabris (University of Connecticut), RiboDynamics

Overview of Current Vendor Solutions for LC-MS Software Solutions for Nucleic Acid Analysis

  • Sanjay Sanghani (Protein Metrics)
  • Thomas Walker (Agilent)
  • Martin Gilar (Waters)
  • Keeley Murphy (Thermo Fisher Scientific)
  • Chris Clark (Bruker)
  • Stephen Kurzyniec (Shimadzu)
  • Mark Hail (Novatia)

Identification by Fragmentation with Mass Spectrometry

  • Dan Fabris (University of Connecticut), Effects of Covalent and Non-Covalent Modifications on the Fragmentation of Oligonucleotide Precursor Ions
  • Ben Garcia (Washington University)
  • Robert Ross (Thermo Fisher Scientific)

Strategies for Optimizing LCMS Analysis in Early Drug Development for Nucleic Acid Therapeutics

  • Xien Yu Chua (Alnylam Pharmaceuticals), Characterizing Single-Stranded Lipophilic siRNA Metabolites in Plasma 
  • Dan Fabris (University of Connecticut), Capillary Electrophoresis Mass Spectrometry for the Analysis of Oligonucleotide Mixtures
  • Tao Wei (GondolaBio)

Quality Control Strategies

  • Camila Ortega (Abzena)
  • Todd Maloney (Eli Lilly)
  • Kui Yang (FDA), Oligonucleotide Active Ingredient Sameness and Impurity Comparability Studies by Mass Spectrometry

Large RNA Modalities

  • Weijing Liu (Thermo Fisher Scientific), Advancing Large RNA Analysis Through Charge Detection Mass Spectrometry
  • Camila Ortega (Abzena)
  • Todd Maloney (Eli Lilly)

Schedule

Wednesday, November 11

Arrivals for out-of-town attendees

Thursday, November 12

7:30 - 8:30 am, Badge Pick-up and Continental Breakfast

8:30 am - 5:00 pm, Workshop Program

5:00 - 6:00 pm, Happy Hour

Friday, November 13

8:00 - 8:30 am, Continental Breakfast

8:30 am - 5:00 pm, Workshop Program

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