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Membrane Proteins and their Complexes:  Mass Spectrometry and Beyond

Organizers: Julian Whitelegge (UCLA), Wendy Sandoval (Genentech), and Michael T. Marty (University of Arizona)


Program Overview

Membrane proteins make up over half of current drug targets, making them an especially important subject for both academic and pharmaceutical research. Because these proteins are inherently insoluble in aqueous solvents and require the presence of lipids or detergents to remain soluble, their analysis by many techniques such as mass spectrometry and X-ray crystallography is challenging. However, over the past 10 to 15 years substantial progress has been made to overcome these hurdles. Only recently has it been possible to obtain mass spectra for intact membrane protein complexes and high-resolution x-ray crystal structures of ion channels and membrane bound receptor molecules.

This conference is dedicated to the mass spectrometry of membrane proteins using a broad range of approaches. This includes applications to structure, biophysics, expression levels, cellular localization, interactions, and function. In addition, we also propose some talks covering complementary analytical techniques, such as X-ray crystallography, NMR, and cryoEM. We envisage this meeting will be topical for the pharmaceutical industry, since many of the current industrial therapeutic targets are membrane proteins.


Preliminary Sessions

Opening Lecture
Art Laganowsky, Texas A&M University

Membrane Protein Sample Preparation
Joe Loo, UCLA
Vicki Wysocki, Ohio State University

Albert Heck, Utrecht University
Iain Campuzano, Amgen Inc.
Nina Morgner, Goethe University Frankfurt
Rosa Viner, ThermoFisher Scientific

Ion Mobility
Brandon Ruotolo, University of Michigan
David Russell, Texas A&M University

Membrane Mimetics
Michael Marty, University of Arizona
James Prell, University of Oregon
Antonio Calabrese, University of Leeds

Biophysical Characterization
Frank Sobott, University of Leeds
Argyris Politis, King's College London
Carla Schmidt, HALOmem, Martin Luther University Halle-Wittenberg

John Yates, Scripps Research Institute
Julian Whitelegge, UCLA
Jenny Brodbelt, University of Texas

Membrane Protein Structural Biology and Biophysics
Jian Payendeh
Ming Zhou, Baylor College of Medicine

Glycosylation and Lipids
Wendy Sandoval, Genentech
Cathy Costello, Boston University School of Medicine
Erin Baker, North Carolina State University

Carol Robinson, University of Oxford

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