Concept 6: Tandem MS

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Further Information


Terms, definitions and standards

What is Mass Spectrometry

Explaining Mass Spectrometry

Objective
Introduction
Statement of the Problem
Solutions
Approach (Methods)
Concept 1: Mass Spectrometer
Concept 2: How is it used
Concept 3: Mass Analysis
Concept 4: Ions and Charge
Concept 5: Ionization Techniques
Concept 6: Tandem MS
Concept 7: Quantification via IDMS
Concept 8: Accuracy and Precision
Summary

Concept 6: Tandem Mass Spectrometry

Simple Definition: Two mass spectrometers joined by a chamber that breaks apart molecules. This definition is appropriate for tandem-in-space but not for tandem-in-time.
	Puzzle analogy

	Word Analogy
	Words Comprised of letters. Arrangement of letters gives words meaning. Special groups of letters make syllables. Common endings = suffixes Talking Writing Playing List all words containg "ing" in the book of abstracts. Use a computer to search for the string "ing" and it displays all words containing "ing."	Molecules Comprised of atoms Arrangement of atoms gives molecules function. Special groups of atoms make functional groups. Common side chains = acids H₂NCH₂COOC₄H₉ H₂NCH(CH₂)COOC₄H₉ H₂NCH(C₆H₅)COOC₄H_{9 Detect all molecules containing a butyl formate functional group from an α-amino acid. Use a NL scan function to detect only molecules that lose a butylformate function group weighing 102 Da.}

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